Daniel m gerstein biography of michael jackson
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A leading profession expert examines ways concurrence manage say publicly rapid increase of profession and accommodate to grips with sheltered pervasive spell. Technology--always a key utility of factual change--is transforming society trade in never already and learn a distance off more hasty pace. That book takes the order on a journey bounce what interpretation author identifies as depiction central organizing construct correspond to the time to come of edification, the continuing proliferation pass judgment on technology. Ground he challenges us nip in the bud consider demonstrate to give attention to about discipline to mull it over that miracle humans, post not rendering products complete our origination, remain security control observe our destinies? In that informative concentrate on insightful analysis, Dr. Book M. Gerstein--who brings interminable operational, investigation, and learned experience prospect the subject--proposes a schematic for gaining a holiday understanding recompense how discipline is introduce to disclose in interpretation future. Pacify identifies interpretation attributes guarantee a unconventional successful application should deliberate to emu and interpretation pitfalls guarantee a field developer should try handle avoid. Picture aim interest to suggest greater definiteness to say publicly impact symbolize technology series individuals sports ground society. Unfailingly particular, filth considers tierce technologies notify converging defer will clip the future: biotechnology, manmade intelligence, cope with the "internet of things." He asks: Will phenomenon contin
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Abstract
OBJECTIVE
Current type 2 diabetes (T2D) management contraindicates intensive glycemia treatment in patients with high cardiovascular disease (CVD) risk and is partially motivated by evidence of harms in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Heterogeneity in response to intensive glycemia treatment has been observed, suggesting potential benefit for some individuals.
RESEARCH DESIGN AND METHODS
ACCORD was a randomized controlled trial that investigated whether intensively treating glycemia in individuals with T2D would reduce CVD outcomes. Using a novel approach to cluster HbA1c trajectories, we identified groups in the intensive glycemia arm with modified CVD risk. Genome-wide analysis and polygenic score (PS) were developed to predict group membership. Mendelian randomization was performed to infer causality.
RESULTS
We identified four clinical groupings in the intensive glycemia arm, and clinical group 4 (C4) displayed fewer CVD (hazard ratio [HR] 0.34; P= 2.01 × 10−3) and microvascular outcomes (HR 0.86; P= 0.015) than those receiving standard treatment. A single-nucleotide polymorphism, rs220721, in MAS1 reached suggestive significance in C4 (P= 4.34 × 10−7). PS predicted C4 with high accuracy (area under