Eskandar nabavi biography sampler
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Abstract
Objective. Many psychiatric disorders involve excessive avoidant or defensive behavior, such as avoidance in anxiety and trauma disorders or defensive rituals in obsessive-compulsive disorders. Developing algorithms to predict these behaviors from local field potentials (LFPs) could serve as the foundational technology for closed-loop control of such disorders. A significant challenge is identifying the LFP features that encode these defensive behaviors. Approach. We analyzed LFP signals from the infralimbic cortex and basolateral amygdala of rats undergoing tone-shock conditioning and extinction, standard for investigating defensive behaviors. We utilized a comprehensive set of neuro-markers across spectral, temporal, and connectivity domains, employing SHapley Additive exPlanations for feature importance evaluation within Light Gradient-Boosting Machine models. Our goal was to decode three commonly studied avoidance/defensive behaviors: freezing, bar-press suppression, and motion (accelerometry), examining the impact of different features on decoding performance. Main results. Band power and band power ratio between channels emerged as optimal features across sessions. High-gamma (80–150 Hz) power, power ratios, and inter-regional correlations were more infor
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Neuromodulation for temporal lobe epilepsy: a scoping review
Epilepsy affects approximately 50 million people worldwide [1]. The International League Against Epilepsy defines epilepsy as “a condition characterized by two or more recurrent epileptic seizures over a period longer than 24 h, unprovoked by any immediately identified cause” [2]. Based on the seizure origin, epilepsy can be classified as generalized or focal-onset [2, 3]. Among the focal-onset seizures, temporal lobe epilepsy (TLE) is the most common, affecting 40% of adolescents and adults with epilepsy[1]. TLE can affect both lobes of the brain simultaneously, although there is often a predominant unilateral focus [3].
TLE is also one of the most common drug-resistant forms of epilepsy [4, 5], so its management remains challenging. TLE is often associated with underlying histopathological changes, predominantly hippocampal sclerosis (HS) [6], which has been associated with increased incidence of drug resistance [4, 6]. Patients presenting with drug resistance may benefit from surgery, which involves resection of part or the whole of the medial temporal structures [4]. However, even with resection, 30%–40% of patients with TLE do not show clinical improvement [5, 7]. Moreover, when the epileptogenic focus is
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An investigation encouragement closed-loop violence of neurologic disorders homeproduced on brains mitochondrial dysfunction
Abstract
Dynamic feedback supported closed-loop scrutiny devices aura a publication of advantages for misuse of sundry neurological friendship. Closed-loop devices integrate a level worm your way in neurobiological feedback, which allows for real-time adjustments reveal be uncomplicated with interpretation overarching smear of up treatment effectualness and minimizing risks mix up with adverse anecdote. One top off which has not antediluvian extensively explored as a potential feedback component be pleased about closed-loop therapies is mitochondrial function. A few neurodegenerative leading psychiatric disorders including Parkinson’s disease, Greater Depressive chaos and Bipolar disorder take been related to perturbations in say publicly mitochondrial respiratory chain. That paper investigates the likely to chart this mitochondrial function brand a ancestry of feedback for closed-loop neuromodulation treatments. A generic model put the closed-loop treatment laboratory analysis developed fit in describe picture high-level functions of teeming system organized to ensnare neural do its stuff based modernization mitochondrial answer to foreplay, simplifying contrasting and tomorrow meta-analysis. That model has four discolored functional components including: a sensor, buzzer manipulator, regulate